NSI-189For research use only. Not for human consumption.
amdiglurax
CAS 1270138-40-3 · 30 × 20 mg · 600 mg total
Out of stock
Dihexa
$39.99 USD
Research use only · Not for human or animal consumption
Batch and analysis
- Release spec
- ≥ 97%
- CAS
- 1270138-40-3
- Systematic name
- amdiglurax
- Presentation
- 30 × 20 mg · 600 mg total
About this compound
For In Vitro Research Use Only – Not for Human or Veterinary Application
NSI-189: found by screening for an effect
Most compounds on our catalog were designed against a known receptor. NSI-189 went the other way. Neuralstem, Inc. picked it out of a phenotypic screen because it stimulated neurogenesis in human hippocampus-derived neural stem cells, and later in mouse hippocampus. Years on, its molecular target still hasn't been identified. It has since received the INN amdiglurax.
Chemistry: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone, a benzylpiperazine-aminopyridine. The free base is C22H30N4O, 366.5 g/mol, CAS 1270138-40-3, PubChem CID 50922681. We supply NSI-189 as the free base (the form described above).
What's been observed
Its activity is described as independent of monoamine reuptake. In cell and animal studies, researchers have linked it to TrkB and Akt activation, higher mitochondrial function and AMPK activity, and higher BDNF and SCF expression. These are downstream readouts, not a binding site.
An unusually wide range of models
| Model | System |
|---|---|
| Hippocampal neurogenesis | Human neural stem cells; mice |
| Angelman syndrome | Mouse model (hippocampal LTP) |
| Ischemic stroke | Rat middle cerebral artery occlusion |
| Cranial irradiation | Rats |
| Diabetic neuropathy | Type 1 and type 2 mouse models; Zucker diabetic fatty rats |
| Oxygen-glucose deprivation | Hippocampal cell cultures |
Most of this work was done by the developer or with it. Neuralstem ran Phase 1 and Phase 2 studies. Newer neurogenesis compounds are now benchmarked against it.
Format
30 capsules of 20 mg NSI-189 free base per bottle.
References
- McIntyre et al. 2017, discovery and profile: PMID 28460574
- Liu et al. 2019, Angelman model and TrkB/Akt: PMID 30408487
- Tajiri et al. 2017, stroke model: PMID 28181668
- Jolivalt et al. 2019, diabetic neuropathy: PMID 31492662
- PubChem: CID 50922681
Disclaimer
This compound has not been evaluated by the FDA. It is not intended to diagnose, treat, cure, or prevent any disease. All use must follow institutional and regulatory guidelines.
Terms of Sale
By purchasing, the buyer affirms they are a qualified researcher or institution. All sales are final. The purchaser assumes full responsibility for handling, use, and regulatory compliance. NSI-189 reference material is supplied for qualified in vitro laboratory research only — not for human or veterinary consumption, administration, compounding, dispensing, diagnostic use, therapeutic use, or patient use.